We are interested how deleterious mutations impact genome evolution with respect to gene order and chromosome number and whether the meiotic recombination (number and distribution of crossing overs) is adapted to handle deleterious load in the genome of yeast.

Using evolutionyry computation we find support for the idea that inbreeding in yeast (mating between spores from the same meiosis) enables effective elimination of accumulated lethal mutations.

Read the paper here, along with an earlier review on the topic.

This movie shows a simulation of genome evolution. Upon selective pressure imposed by mutations in essential genes, genomes of yeast-like (digital) species evolve non-random distributions of essential genes and meiotic recombination hot spots.