Welcome to the

... basic research and methods for cell biology 





Covid-19 Pandemic

Our lab has contributed to the development of an RT-LAMP based SARS-CoV-2 coronatest and we are operating since August 2020 a > Corona test station. We use the test station to run scientific corona > sentinel studies  (Virusfinder, Virusdetektiv) and we offer > Coroantests for Students and faculty of the University of Heidelberg

Some of our publications


Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase

Kong KYE*, Fischer B*, Meurer M*, Kats I, Li Z, Rühle F, Barry JD, Kirrmaier D, Chevyreva V, San Luis BJ, Costanzo M, Huber W, Andrews BJ, Boone C, Knop M#, Khmelinskii A#

 (2021) Mol Cell DOI: 10.1016/j.molcel.2021.04.018

A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples

Viet Loan Dao Thi*, Konrad Herbst, Kathleen Boerner, Matthias Meurer, Lukas PM Kremer, Daniel Kirrmaier, Andrew Freistaedter, Dimitrios Papagiannidis, Carla Galmozzi, Megan L Stanifer, Steeve Boulant, Steffen Klein, Petr Chlanda, Dina Khalid, Isabel Barreto Miranda, Paul Schnitzler, Hans-Georg Kräusslich, Michael Knop* and Simon Anders* (2020)

Science translational medicine DOI:10.1126/scitranslmed.abc7075

CRISPR-Cas12a–assisted PCR tagging of mammalian genes.

Fueller J, Herbst K, Meurer M, Gubicza K, Kurtulmus B, Knopf JD, Kirrmaier K, Buchmuller BC, Pereira G, Lemberg MK, Knop M (2020)

J Cell Biol (2020) 219 (6): e201910210

Pooled clone collections by multiplexed CRISPR-Cas12a-assisted gene tagging in yeast.

Buchmuller, B.C., Herbst, K., Meurer, M., Kirrmaier, D., Sass, E., Levy, E.D., and Knop, M. (2019)

Nat Commun 10, 2960

Genome-wide C-SWAT library for high-throughput yeast genome tagging.

Meurer M, Duan Y, Sass E, Kats I, Herbst K, Buchmuller BC, Dederer V, Huber F, Kirrmaier D, Stefl M, Van Laer K, Dick TP, Lemberg MK, Khmelinskii A, Levy ED & Knop M

(2018) Nat Methods 15: 598–600

Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis

Durrieu L, Kirrmaier D, Schneidt T, Kats I, Raghavan S, Hufnagel L, Saunders TE & Knop M

Mol. Syst. Biol. 14: e8355 (2018)

Mapping Degradation Signals and Pathways in a Eukaryotic N-terminome. ​

Kats I, Khmelinskii A, Kschonsak M, Huber F, Knieß RA, Bartosik A & Knop M

Mol. Cell 70: 488–501 (2018)

Protein quality control at the inner nuclear membrane

Khmelinskii A, Blaszczak E, Pantazopoulou M, Fischer B, Omnus DJ, Le Dez G, Brossard A, Gunnarsson A, Barry JD, Meurer M, Kirrmaier D, Boone C, Huber W, Rabut G, Ljungdahl PO & Knop M Nature 516: 410–413 (2014)

This is us

people in the lab

Michael Knop


Dan Lou


Konrad Herbst

PhD Student in Biology

Krisztina Gubicza

PhD Student in Biology

Hans Hombauer

Scientific Visitor

Ioannis Papaioannou


Matthias Meurer


Yuan Qiang Duan

PhD Student in Medicine

Christian Reinbold

PhD Student in Biology

Diana Ruethnick


Daniel Kirrmaier


Junhua Wan

PhD Student in Biology

Ramakrushna (Ram) Swain

PhD Student in Biology


How to get in touch or reach us


+49 6221 544213


Karin Klingmann or Kornelia Mack

+49 6221 54 6830/6831


Im Neuenheimer Feld 282

69120 Heidelberg


For Strain and plasmid requests, please dont forget to include:
- title of the publication 
- the exact name(s) of strain(s) or plasmid(s)
- your address
if courier shipping is preferred:
please provide a DHL or FEDEX number

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