Welcome to the

... basic research and methods for cell biology 





A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples

Viet Loan Dao Thi*, Konrad Herbst, Kathleen Boerner, Matthias Meurer, Lukas PM Kremer, Daniel Kirrmaier, Andrew Freistaedter, Dimitrios Papagiannidis, Carla Galmozzi, Megan L Stanifer, Steeve Boulant, Steffen Klein, Petr Chlanda, Dina Khalid, Isabel Barreto Miranda, Paul Schnitzler, Hans-Georg Kräusslich, Michael Knop* and Simon Anders* (2020) Science translational medicine DOI:10.1126/scitranslmed.abc7075

CRISPR-Cas12a–assisted PCR tagging of mammalian genes.

Fueller J, Herbst K, Meurer M, Gubicza K, Kurtulmus B, Knopf JD, Kirrmaier K, Buchmuller BC, Pereira G, Lemberg MK, Knop M (2020)

J Cell Biol (2020) 219 (6): e201910210

Pooled clone collections by multiplexed CRISPR-Cas12a-assisted gene tagging in yeast.

Buchmuller, B.C., Herbst, K., Meurer, M., Kirrmaier, D., Sass, E., Levy, E.D., and Knop, M. (2019)

Nat Commun 10, 2960

Genome-wide C-SWAT library for high-throughput yeast genome tagging.

Meurer M, Duan Y, Sass E, Kats I, Herbst K, Buchmuller BC, Dederer V, Huber F, Kirrmaier D, Stefl M, Van Laer K, Dick TP, Lemberg MK, Khmelinskii A, Levy ED & Knop M

(2018) Nat Methods 15: 598–600

Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis

Durrieu L, Kirrmaier D, Schneidt T, Kats I, Raghavan S, Hufnagel L, Saunders TE & Knop M

Mol. Syst. Biol. 14: e8355 (2018)

Mapping Degradation Signals and Pathways in a Eukaryotic N-terminome. ​

Kats I, Khmelinskii A, Kschonsak M, Huber F, Knieß RA, Bartosik A & Knop M

Mol. Cell 70: 488–501 (2018)

Protein quality control at the inner nuclear membrane

Khmelinskii A, Blaszczak E, Pantazopoulou M, Fischer B, Omnus DJ, Le Dez G, Brossard A, Gunnarsson A, Barry JD, Meurer M, Kirrmaier D, Boone C, Huber W, Rabut G, Ljungdahl PO & Knop M Nature 516: 410–413 (2014)

This is us

people in the lab

Michael Knop


Matthias Meurer


Yuan Qiang Duan

PhD Student in Medicine

Krisztina Gubicza

PhD Student in Biology

Darshana Kalita

PhD Student in Biology

Ioannis Papaioannou


Daniel Kirrmaier


André Schulze

PhD Student in Medicine

Christian Reinbold

PhD Student in Biology

Ute Wieden-Kothe

Sabbatical Visitor

Diana Ruethnick


Konrad Herbst

PhD Student in Biology

Junhua Wan

PhD Student in Biology

Julia Füller

PhD Student in Biology

Hans Hombauer

Scientific Visitor


How to get in touch or reach us


+49 6221 544213


Karin Klingmann or Kornelia Mack

+49 6221 54 6830/6831


Im Neuenheimer Feld 282

69120 Heidelberg


For Strain and plasmid requests, please dont forget to include:
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© 2019 By Michael Knop.